Epliron Tablet 25mg

Epliron Tablet 25mg is a selective mineralocorticoid receptor antagonist containing eplerenone (25mg). It acts by competitively binding to mineralocorticoid receptors in the renal cortical collecting duct, blocking aldosterone interaction. This inhibition suppresses aldosterone-mediated sodium and water reabsorption while conserving potassium ions. Consequently, it promotes modest natriuresis, reduces intravascular volume, lowers blood pressure, and attenuates aldosterone-driven myocardial and vascular fibrosis without causing the endocrine side effects associated with non-selective agents like spironolactone.Clinically, Epliron 25mg is indicated to reduce cardiovascular mortality and heart failure hospitalizations in post-myocardial infarction patients with left ventricular systolic dysfunction ($LVEF \le 40\%$) and clinical heart failure, as well as for managing essential hypertension.The standard starting dose is 25mg once daily, titrated up to 50mg once daily as tolerated, provided baseline serum potassium is $ 5.5\text{ mEq/L}$ at initiation), severe renal impairment ($CrCl < 30\text{ mL/min}$), or concomitant strong CYP3A4 inhibitor therapy. Common side effects include hyperkalemia, dizziness, fatigue, hypotension, diarrhea, and mild serum creatinine elevations.

Price: Rs. 288.00

• Manufacturer
  Highnoon Laboratories Ltd. (Pakistan)
• Generic name
  Eplerenone
• Pack size
  1 Box = 2 Strip | 1 Strip = 7 Tablet
• Availability
  In stock
• Prescription required
  Yes